Milk EV

Extracellular vesicles (EV) are a heterogeneous family of lipid bilayer-bound vehicles originating from the endosome or plasma membrane. Once EV arrive to their target cell, they can change cell physiology by triggering a receptor-mediated intracellular response or by depositing their molecular cargo within the recipient’s cytosol after fusion or endocytosis. The role of extracellular vesicles (EV) on livestock health is largely unknown because only recently EV have been considered one of the most important components in intercellular communication and inflammatory response modulation. The main goal of our research is to unravel the participation of EV in mammary gland cells physiology and pathology by doing basic research on cutting-edge molecular biology approaches. At the same time, we aim to introduce new mammary gland 3D in vitro models for functional studies that strategically complement the use of animals in research.